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Macromolecular proton fraction (MPF) represents the relative amount of semi-solid macromolecules involved in magnetization transfer with free water protons. In this work, we reported a novel MPF quantification method based on spin-lock for rapid MPF mapping. The total scan time for 3D brain MPF measurement can be achieved within five minutes. We demonstrated the proposed method via simulation, phantom and in vivo experiments.
Hou et al. (Wed,) studied this question.