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We performed a deuterium metabolic imaging (DMI) investigation of two deuterated probes with different metabolic properties: 1) the glucose analog 2,2’-2H2-deoxy-D-glucose (2H22DG) which gets intracellularly trapped after being phosphorylated by hexokinase; and 2) 6,6′-2H2-D-glucose (2H2Glc) which undergoes full oxidative catabolism. We tested their potential to detect metabolic impairment in a mouse model of Alzheimer’s disease. Our results demonstrated that the accumulation / metabolism of these two glucose derivatives can be detected dynamically in the mouse brain, and that DMI can detect disrupted glucose metabolism in an AD model.
Gao et al. (Wed,) studied this question.