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Knockdown of Cbx2 in a syngeneic mouse model of HGSC leads to shift in composition of the TIME. A, Diagram of ID8 syngeneic mouse model. B, RT-PCR analysis confirming Cbx2 knockdown in ID8 Trp53−/−Brca2−/− cells (internal control, 18S), C, Tumor dissemination sites and (D) total tumor weight of knockdown vs. control tumors. E, NanoString transcriptomic differential expression of shCbx2 compared with control, derived from solid tumors. F, NanoString pathway scores for cell proliferation, cytokine signaling score, immune cell and migration score, and myeloid comparison score between control and shCbx2. G, Comparison of CD3+ (T cells) and F480 (macrophages) without Ki67 positivity and (H) with Ki67 positivity in control vs. shCbx2. Error bars, SEM. Statistical test, unpaired t test and multicomparison ANOVA.
Iwanaga et al. (Mon,) studied this question.