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Proteostasis, the intricate balance of protein synthesis, folding, trafficking, and degradation, is a fundamental cellular process crucial for maintaining cellular health and homeostasis. Imbalances in proteostasis are implicated in various diseases, including neurodegenerative disorders, cancer, aging, type 2 diabetes mellitus, cataract, huntington's disease, heart disease, sarcopenia, ischemic disorders, diabetic neuropathy and other metabolic conditions. We delve in to the proteostasis mechanisms and highlight the significance of proteostasis in the context of protein misfolding diseases that have broadened our understanding of proteostasis network. Further, we explore the relevance of proteostasis in cancer, shedding light on the interplay between the ubiquitin-proteasome system and oncoproteins. Furthermore, we also address therapeutic approaches aimed at modulating proteostasis to combat protein misfolding diseases. The mysteries of protein balance continue to captivate researchers, and the evolving landscape of proteostasis research promises insights into novel therapeutic strategies and a deeper understanding of its role in human health. This review offers a comprehensive perspective on the ever-expanding frontiers of proteostasis research, with the hope of inspiring further exploration and innovation in this dynamic field.
Shukla et al. (Wed,) studied this question.