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Transdermal drug delivery system is widely used for the administration of various dosage forms such as gel, patch spray but they have some drawbacks to overcome these drawbacks new techniques for administering drugs to the skin were explored by creating film-forming polymeric solutions. The objective of this study was to develop a film-forming spray formulation to treat inflammation. The formulation was developed by combining polymers, penetration enhancer, plasticizer, and a suitable solvent system. The central composite design with 2 independent variables and 3 dependent variables is implemented to optimize the formulation and which was given 12 runs. The film-forming spray was put through its tests to assess formulation and container-related parameters such as, spray angle, volume delivered for one actuation and. From the study, it was observed that the concentration of ethyl cellulose and Eudragit l-100 has a greater influence on the viscosity of the spray solution, drying time, whereas the eutectic mixture has a greater influence on the drug permeation followed by the polymers. It also tested for anti-inflammatory activity with carrageenan induced paw edema volume and it was found that formulation showed better anti-inflammatory activity. The study has concluded that the formulated film-forming spray formulation is highly efficient in treating transdermal inflammation when compared to the traditional dosage forms.
Swati et al. (Thu,) studied this question.
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