Association between biological aging and Asthma-COPD overlap based on Nhanes 2005-2018

Abstract BACKGROUND Aging is an important factor in the pathogenesis of various respiratory diseases, and biological aging can better reflect the systemic functional status of individual organisms. The purpose of this study was to analyze the association between biological aging and Asthma-COPD Overlap (ACO) ,and to explore its potential causal relationship. METHODS The present study utilized data from the National Health and Nutrition Examination Survey (NHANES), spanning from 2005 to 2018. Three biological ages Klemera-Doubal method (KDM), phenotypic age (PhenoAge) and homeostatic dysregulation (HD) and two measures of biological acceleration of aging (BioAgeAccel and PhenoAgeAccel) were selected as the main exposure factors for analysis. Weighted logistic regression and restricted cubic spline regression were used to analyze the association between biological aging and ACO. RESULTS In our study, phenotypic age was positively associated with the incidence of ACO, and the degree of phenotypic age acceleration was also a risk factor for ACO prevalence. After further adjustment for demographic characteristics, both remained an important risk factor for ACO. CONCLUSION This study provides some evidence for the association of biological aging in the development of ACO. In addition, preventive strategies targeting aging have a potential role in reducing the risk of ACO.