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Low-grade adenosquamous carcinoma (LGASC) is a rare variant of metaplastic breast carcinoma that consists of glandular and squamous elements in a spindle cell background. They lack distinctive imaging features and overlap with other breast neoplasm characteristics, posing a diagnostic challenge. We present the case of a 60-year-old woman with metachronous bilateral invasive breast carcinoma (MBBC). The mastectomy specimens of her left breast carcinoma revealed nests of squamous- appearing cells and "comma" glandular structures on a microscopic level. Comprehensive immunohistochemical examination of ER, PR, Her-2, p63, and CK7 CK5/6 confirmed the diagnosis of LGASC. Unlike other invasive breast carcinomas, LGASC have an indolent course and favorable prognosis. Eight years after surgery, she was diagnosed with a non-specific type of invasive breast carcinoma of the right breast via imaging, core needle biopsy and immunohistochemistry. This was a rare case of MBBC that has not been previously reported. Therefore, we report and review the relevant literature to raise awareness of this disease.
He et al. (Sun,) studied this question.