July 10, 2024Open Access

Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma

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Abstract

Airway epithelial cell (AEC) necroptosis contributes to airway allergic inflammation and asthma exacerbation. Targeting the tumor necrosis factor-like ligand 1 A (TL1A)/death receptor 3 (DR3) axis has a therapeutic effect on asthmatic airway inflammation. The role of TL1A in mediating necroptosis of AECs challenged with ovalbumin (OVA) and its contribution to airway inflammation remains unclear.

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Liu et al. (Wed,) studied this question.

synapsesocial.com/papers/68e60ad6b6db64358759ea55 https://doi.org/https://doi.org/10.1186/s12931-024-02900-4

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