Figure S4 from Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer

Figure S4. GSEA analysis of BHLHE40 in GSE39582 and cell–cell communication of CXCL1+ CAFs and SFRP2+ CAFs. (A) Enrichment plot of the EMT signaling, the angiogenesis, and the TGFβ signaling of the BHLHE40 high and BHLHE40 low groups in GSE39582. (B) Dot plot of expression of top 30 active ligands in CXCL1+ CAFs and SFRP2+ CAFs. (C) Heatmap of top 30 active ligands in SFRP2+ CAFs sorted by AUPR values. (D) Heatmap of top 30 active ligands and predicted target genes in CXCL1+ CAFs. (E) Heatmap of top 30 active ligands and predicted receptors in CXCL1+ CAFs.