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Introduction: (1) The leading cause of mortality in burn injured patients is sepsis, accounting to 34.4% of deaths according to a recent study . The (2) loss of cutaneous barrier allows microbes to easily enter the body and cause skin and blood borne infection . Some studies have reported that (16,17) Procalcitonin is a useful marker for sepsis in severe burn injury . Therefore, this study is an to attempt to assess the clinical signicance of procalcitonin in burn patients as an early indicator of sepsis. Aim: To study the value of Procalcitonin levels as a prognostic biomarker for sepsis in thermal burn injured patients. Material And Methods: Type Of Study: Observational study Study Duration: 2 months Study Design:Cross-sectional study. A total of 25 subjects of burns were included in this study. Burn injured patients with burn size 20- 50% TBSA and age 18-50 years old, admitted in Plastic Surgery in-patient department were included in this study. The study was conducted in a Government tertiary care hospital, Hyderabad. Blood samples were obtained from each patient for measurement of serum procalcitonin(PCT)) after 48 hours (day 3) after the burn injury and at 120 hours (day 5). Results: With increasing TBS burn involvement there is gradual increase in ProCalcitonin levels which was found to be signicant on Day 3 and Day 5 with p value of 0.048 and 0.005 on Day 5 respectively by ANOVA test. Conclusion: Procalcitonin can be used as a reliable and predictive biomarker for the early diagnosis of sepsis in burn injured patients.
Singoori et al. (Mon,) studied this question.