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Abstract Background: Odisha state, one of the leading contributors to the malaria burden in India as it accounted for around 27% of India’s malaria cases having 17.6% of all reported deaths. It has been seen that the cytokines, both pro-inflammatory and anti-inflammatory can be taken as the markers for both complication or severity of Malaria. Hence our study is essentially meant to study cytokines in both vivax and falciparum of malaria in our area. Methods: Haematological parameters like Haemoglobin, Platelet count and other hematocrit was accessed. From serum part biochemical tests like Liver function test, Blood sugar levels, Kidney function test and Glucose 6- Phosphate dehydrogenase (G6PD) was done. From the serum cytokines study particularly pro and anti-Inflammatory cytokines were done involved in Malaria. Results: Out of 39 cases9 were severe and 30 nonsevere malaria.The mean age of cases in severe malaria was 42.72 ± 17.14 years and 36.17 ±14.07 years in nonsevere malaria.IL1b levels were higher in both vivax and falciparum malaria.IL-4 levels are lower in non-severe malaria compared to severe group.. IL-6, IL-7 levels in non-severe and severe groups, IL-8 levels were very high in falciparum and IL-9 levels were lower in malaria cases whereas IL-10 , TNF-alpha levels were higher. Conclusion: IL-8 and IL-1b both can be taken as marker in severe malaria infection. As it is often difficult to assess the progression and severity of malaria in the early stages, these arrays of cytokines can be useful in diagnostic as well as prognostic purpose.
Patnaik et al. (Thu,) studied this question.