FIGURE 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

DEGs between responders and nonresponders in the cancer compartment. A, Heat map of genes consistently differentially expressed across discovery cohorts in the cancer cells. Heat maps are colored by the log2 fold change of gene expression. P-values of individual cohorts are combined using the Fisher method, and the −log10(meta P-value) is presented in the bar plot. Genes with q-value P-value B, Bar plot shows the number of significant genes found in the stroma and cancer compartment at different q-value cutoffs. Pathway analysis of genes with cancer-specific expression differences in gastric cancer (C) and urothelial cancer (E). Bar plots of deconvoluted cancer expression of DEGs in the top enriched pathway in gastric cancer (D) and urothelial cancer (F). Error bars represent estimated SE.