Key points are not available for this paper at this time.
Abstract This article presents an efficient one-step synthesis of tetrahydropyrazolo1,5-apyrimidines through the recyclization of N-arylitaconimides with aminopyrazoles. The heterocyclic system of pyrazolo3,4-bpyrimidine is known for its diverse biological properties, making its derivatives significant in pharmaceutical and medicinal chemistry. The study focuses on the regio- and chemoselective cascade reaction of N-arylitaconimides with 5-aminopyrazoles, demonstrating a new approach to synthesizing pyrazolo1,5-apyrimidines and pyrazolo3,4-bpyridines. The methodology, involving boiling in isopropyl alcohol with acetic acid, yields selectively either pyrazolo3,4-bpyridines or pyrazolo1,5-apyrimidines based on the substituents in the aminopyrazoles. The study elucidates the reaction mechanism, structural characterization using NMR spectroscopy, and confirms the structures via high-performance liquid chromatography and mass spectrometry. The simplicity and synthetic potential of this approach make it a valuable method for the preparation of these heterocyclic frameworks.
Shmoylova et al. (Thu,) studied this question.