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Rats (11 groups) were treated with malathion (MAL) and probiotic bacteria for 6 weeks. The results obtained in kidney showed a significant increase in the malondialdehyde (≈92%), superoxide dismutase (≈41%), catalase (≈56%), IL-1β (≈45), and TNF-α (≈25%) in MAL-treated group. In contrast, testicular catalase, superoxide dismutase, and TNF-α levels decreased ≈ 33, 30, and 21%, respectively, in the MAL-treated groups. In kidney, treatment with the probiotics reduced malondialdehyde and catalase activity compared with the MAL-treated group. As well as, treatment with the L. rhamnosus, L. casei, L. plantarum, and L. acidophilus enhanced testicular catalase activity (≈21, 49, 52, and 26%, respectively) compared with the MAL-treated group. Unlike superoxide dismutase, in groups treated with L. plantarum, L. rhamnosus, inflammatory factor levels decreased in kidney compare with MAL-group. In testis, probiotic bacteria blocked MAL effect on malondialdehyde, catalase and TNF-α. Micrographs of kidney sections of the MAL revealed mild to moderate proximal and distal tubular cell necrosis. Histopathological evaluation of the L. acidophilus sample revealed less tissue toxicity in comparison to MAL group. Micrographs of testis sections of the showed no histological changes. Probiotics could effectively protect against malathion-induced damage in kidneys and testes, offering a potential solution for pesticide-related toxicity.
Sayadi et al. (Thu,) studied this question.