Figure S4 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity

Fig. S4. a. Effect of hits from the HTS on proteasome ChT-like activity on ARH-77 and U266 MMCLs. Proteasome ChT-like activity was determined with 50,000 ARHG-77 or U266 cells/well after 24 h of incubation with 50 uM LLVY-R110. b. Effect of proteasome inhibitors on proteasome ChT-like activity in three different MMCLs. Bortezomib, carfilzomib and ixazomib were added to MM cells at indicated concentrations. Proteasome ChT-like activity was then determined after 24 h incubation.