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Pharmacognosy Research,2024,16,3,574-580.DOI:10.5530/pres.16.3.68Published:June 2024Type:Original ArticleAuthors:Kondeti Ramudu Shanmugam, Meesala Guru Sekhar, Chilakala Ramakrishana, and Kesireddy Sathyavelu Reddy Author(s) affiliations:Kondeti Ramudu Shanmugam1,*, Meesala Guru Sekhar2, Chilakala Ramakrishana3, Kesireddy Sathyavelu Reddy4 1Department of Zoology, PRR and VS Government Degree College, Vidavalur, SPSR Nellore, Andhra Pradesh, INDIA. 2Department of Zoology, Government Degree College, Cumbum, Prakasam, Andhra Pradesh, INDIA. 3Department of Marine Bio-Food Sciences, College of Fisheries and Ocean Sciences, Chonnam National University, Yeosu, SOUTH KOREA. 4Department of Zoology, Division of Molecular Biology and Ethanopharmacology, Sri Venkateswara University, Tirupati, Andhra Pradesh, INDIA. Abstract:Background: Diabetes affects each and every part of the human body and is a chronic health condition. About 422 million people worldwide have diabetes and 1.5 million deaths are directly attributed to diabetes each year. Objectives: The aim of this study was to investigate the effect of ginger on ATPases (Na+/K+, Mg2+ and Ca2+) activities and Malondialdehyde (MDA) levels in the mitochondrial fractions of Hypothalamus (HT), Cerebral Cortex (CC), Hippocampus (HC) and Cerebellum (CB) of diabetic rats. Materials and Methods: 30 wistar strain albino rats are divided into five groups Normal Control (NC), ginger treatment (Gt), diabetic control (DC), Diabetic+Ginger (D+Gt) and Diabetic+Glibenclimide (D+Gli). Na+/K+, Mg2+Ca2+ MDA levels and liver markers estimated in all the groups. Results: Diabetic rats showed depletion in Na+/K+, Mg2+Ca2+ activities, body weights, plasma insulin and elevation in MDA levels in brain structures. Whereas blood glucose levels increased and liver markers Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatise (ALP) are elevated in diabetic rats. Our results suggest that ginger treatment prevent the diabetes induced depletion of brain ATPases, body weights, insulin and MDA, thus enabling to preserve brain function in regulation of intracellular homeostasis of Na+ /K+, Mg2+, Ca2+ ions. Blood glucose, plasma insulin, body weights and liver markers are also normalized with ginger supplementation in diabetic rats. Conclusion: Our findings may suggest that ginger treatment may decrease the diabetes associated neuronal dysfunction. Further our histopathological study also proves that ginger protected brain cells from diabetic induced oxidative stress. Our study indicates that ginger treatment may reduce neuronal complications during diabetes condition. Keywords:ATPases, Brain regions, Diabetes, Ginger, MDA, RatsView:PDF (409.38 KB)
Shanmugam et al. (Fri,) studied this question.