1246-P: Maternal Proinflammatory Markers Associate with Obesity and Glycemic Measures in Pregnancy

Introduction 33% had diabetes. We analyzed baseline glycemic measures (fasting glucose, insulin, C-peptide, HbA1c), proinflammatory biomarkers (IL-6, hsCRP), and maternal leptin. Results: Mean age was 29.9 years (SD ±6.3), mean pregestational BMI was 33.1 kg/m2 (SD±9.4). Table 1 shows significant positive Spearman correlations between maternal serum IL-6 and hsCRP with pregestational BMI, insulin, HbA1c, C-peptide, and leptin. There was no significant correlation between pregestational BMI and offspring birth weight. In a subset (n=40) of matched samples maternal IL-6 was correlated with cord-blood leptin (r=0.34, p=0.03) and TNF-α (r=0.31, p=0.04). Conclusion: Gestational maternal proinflammatory cytokines were elevated in women with excess adiposity and hyperglycemia. Maternal IL-6 associated with fetal adipocytokines, however, additional data are needed to explore this relationship and its impact on fetal growth and development. Disclosure L. Vazquez: None. E. Vazquez Arreola: None. H.C. Looker: None. R.L. Hanson: None. D. Wasak: None. R. Caballero: None. M. Sinha: None.