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Abstract Purpose of review Alternatives to surgical management of breast disease is desired by patients wishing to avoid an operation or those who are not a candidate for surgery. The role of cryoablation for treatment of benign and malignant tumors is reviewed to determine optimal candidacy. Recent findings Cryoablation is safe, effective, and well tolerated by patients. Cryoablation is being increasingly utilized to treat a subset of patients with primary breast cancer and is most effective when treating small lesions without extensive intraductal component. Combination with immunotherapy can enhance response to treatment. Summary Further studies are needed to determine if cryoablation is sufficient as de-escalation of other adjuvant treatments continues for patients with early-stage breast cancer. Combination of cryoablation with immunotherapy or treating the primary tumor in the presence of metastatic disease may optimize systemic therapies and patient outcomes.
Kopicky et al. (Mon,) studied this question.