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The current investigation was pointed at developing and progressively validating novel, simple, responsive and stable RP-HPLC method for the measurement of active pharmaceutical ingredients of Nirmatrelvir and Ritonavir and their related substances.RP-HPLC methodology was used for the quantitative determination of Nirmatrelvir and Ritonavir.Sunfire C18 Column, (5 µm, 4.6 mm X 250 mm) using mobile phase of 0.01N KH2PO4: Acetonitrile: Methanol (80:20:10 v/v) with flow rate of 1 ml/min (Detection wavelength 238 nm) was used for the present study.Using the impurity-spiked solution, the chromatographic approach was streamlined.The proposed method to be fast, simple, feasible and affordable in RS condition.During stability tests, it can be used for routine analysis of production samples and to verify the quality of drug samples during stability studies.
Soujanya et al. (Sat,) studied this question.
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