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Background: It is well known that SLE is the autoimmune disorders with predominate musculoskeletal injuries such as arthritis, myositis etc. which could affect patients physical activity and life quality. Therefore, the real state of body composition state in SLE patients and its impact on functional activity and life quality is still unclear. Objectives: The aim of this study was to evaluate body composition status of SLE patients compared to healthy controls and to investigate its association with physical performance and life quality. Methods: This cross-sectional study includes 31 women with SLE of mean age 45,3±7,0 years with mean disease duration 9,7±4,6 years and 29 healthy age and sex-matched subjects. Body composition status (fat mass total/lean mass total/appendicular skeletal muscle mass (ASSM)/appendicular skeletal muscle index (ASMI) was mesaured by dual-energy X-ray absorbtiometry (DXA). Muscle function was evaluated by grip strength with handheld-dynamometer and by chair stand test. Life quality was measured by HAQ and SF-36 questionnaires in both groups. The Asian Working Group criteria on Sarcopenia (2019) were used as cut-off point for low muscle strength, muscle mass and physical performance. Statistical analysis was conducted with a t-test for mean difference, and linear regression was used to adjust confounders. Results: The SLE patients showed significantly differences in all body composition measurments compared to healthy control group. Thus the mean lean mass total/ASSM/ASMI were significantly lower in SLE group than in healthy controls (46403,02±2533,5gram vs 52856,6±45435.8gram (p±1199,3 gram vs 24745,2±2389,7gram (p±4072,5 gram vs 27943,6±3074,9 gram). The muscle function of SLE patients was also significantly lower than in control group (21,0 ±8,7 kg vs 30,6±9,3 kg by grip strength and 7,4±1,5 sec. vs 12,7±1,3 sec. by chair test pConclusion: SLE patients showed significant disproportion in body composition compared to general population. Lower ASSM and ASMI are the predictors of limited physical activity and poorer life quality of patients with SLE. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.
Seheda et al. (Sat,) studied this question.