Ab0688 the Relationship Between Dietary Inflammatory Index Scores and Rheumatoid Arthritis Disease Activity

Background: Many patients diagnosed with rheumatoid arthritis (RA) report relief of symptoms after eating certain foods. Previous research shows positive effects of food and food components on clinical outcomes in RA, but there is insufficient evidence to provide specific dietary advice. Diet plays an important role in regulating the inflammation seen in rheumatoid arthritis. Objectives: Our aim is to investigate the relationship between Dietary Inflammation Index (DII) scores and RA activity. Methods: Forty-one RA patients were enrolled in the study. The general inflammatory index of the diet was analyzed by recording the 24-hour food consumption of the patients, and the nutrients were analyzed using the Nutrition Information Systems Package Program. Dietary inflammatory indices were calculated for each patient using the patients' macro and micronutrient intake levels. RA disease activity was assessed using the Disease Activity Score-28 (DAS-28). Results: The DAS-28 score was lower in the anti-inflammatory diet group compared to the pro-inflammatory diet group (p=0.163) (Table 1). A weak but significant relationship was found between diet inflammation index score and DAS-28 (r=0.3468, p=0.0263). The effect of the dietary inflammatory index on the DAS-28 was %12,02 (Figure 1). Dietary iron, vitamin C, niacin, and magnesium intakes were statistically significantly higher in the quartile group that received an anti-inflammatory diet than in the quartile group that received a pro-inflammatory diet. The intake of some micronutrients, such as iron, zinc, magnesium, and folic acid, was significantly lower than the recommended values in all RA quartile groups (Table 1). Conclusion: Our results suggest that reducing inflammation through the diet may have a weak but significant effect in controlling disease activity in RA patients. REFERENCES: 1 Forsyth C, Kouvari M, D'Cunha NM, Georgousopoulou EN, Panagiotakos DB, et al. The effects of the Mediterranean diet on rheumatoid arthritis prevention and treatment: a systematic review of human prospective studies. Rheumatol Int. 2018; 38:737-747. 2 Gomez EF, Kaufer-Horwitz M, Mancera-Chavez GE. Medical nutrition therapy for rheumatic disease in: Mahan KL, Raymond JL, editors. Krause's Food 2017.p.(790-805). Acknowledgements: NIL. Disclosure of Interests: None declared.