May 8, 2024

Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts

GKGeorgios KokkotisNational and Kapodistrian University of Athens EFEirini FilidouNovo Nordisk Foundation GTGesthimani TarapatziDemocritus University of Thrace

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Abstract

Oncostatin-M (OSM) is associated with antitumor necrosis factor (anti-TNF)-α resistance in inflammatory bowel disease (IBD) and fibrosis in inflammatory diseases. We studied the expression of OSM and its receptors (OSMR, gp130) on intestinal subepithelial myofibroblasts (SEMFs) and the effect of OSM stimulation on SEMFs.

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Kokkotis et al. (Wed,) studied this question.

synapsesocial.com/papers/68e6b01bb6db643587631722 https://doi.org/https://doi.org/10.1093/ibd/izae098

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