Prevalence of Vancomycin Resistant Enterococcus in Various Clinical Specimens in Tertiary Care Hospital

Introduction: Enterococcus is a commensal of the genitourinary tract and gastrointestinal. Recently, they have been recognised as pathogens of medical significance linked to infections acquired in both hospitals and the community. In patients with compromised immune systems, hospital-acquired infections are most commonly caused by VRE. Consequently, because of the high morbidity and fatality rate of VRE, treatment is crucial. Estimating the prevalence of VRE in diverse clinical specimens is the goal of this research. Materials and methods: A prospective observational investigation was performed in the Department of Microbiology, GMC, Ongole, AP from April 2023 to August 2023. Three hundred samples were taken from blood, urine, and OPD exudates in IP patients of every age and sexuality. AST and enterococcus were anticipated to be detected using the Kirby-Bauer disc diffusion method. MIC was estimated for every isolate of Enterococcus using the E test. Results: Out of 300 samples, 56 were Enterococcus isolates from 25 (45%) urine, 18(32%) blood, and 13(23%) exudates. Out of 56, 32(57%) E. faecalis, 24 (43%) E. faecium. VRE was detected from 04 (45%) urine, 03(33%) blood, and 02(22%) Exudates. Conclusion: In this study, 16% of VRE were found. Multidrug resistance has made Enterococcus a potential pathogen in modern times. Therefore, in order to prevent dissemination, an effective infection control programme, and routine surveillance must be implemented. Antibiotic stewardship must be properly followed to reduce antibiotic resistance (ABR).