May 2, 2024Open Access

Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease

KVKateřina VeverováCharles University JLJan LaczóCharles University AKAlžběta KatonováCharles University

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Abstract

Defective mitophagy is consistently found in postmortem brain and iPSC-derived neurons from Alzheimer disease (AD) patients. However, there is a lack of extensive examination of mitophagy status in serum or cerebrospinal fluid (CSF), and the clinical potential of mitophagy biomarkers has not been tested. We quantified biomarkers of mitophagy/autophagy and lysosomal degradation (PINK1, BNIP3L and TFEB) in CSF and serum from 246 individuals, covering mild cognitive impairment due to AD (MCI-AD,

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Veverová et al. (Thu,) studied this question.

synapsesocial.com/papers/68e6bbd2b6db64358763c971 https://doi.org/https://doi.org/10.1080/15548627.2024.2340408

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