Targeting tumor-associated macrophages for anti-cancer activity and its pathway

• The complex signalling networks and transcription factors that regulate TAM polarization and function in the tumor microenvironment. • The therapeutic applications of targeting TAMs for anti-cancer action and the obstacles of developing successful treatments. • The potential of TAM-targeted therapeutics to revolutionize cancer therapy and improve patient outcomes, as well as future research initiatives. • Discover how tumor-associated macrophages (TAMs) affect cancer growth and therapy resistance.