Pd38-09 Pathological Complete Response to Neoadjuvant Chemotherapy Improves Antitumor Immune Response Through Reduction of Regulatoty T Cells in Muscle-Invasive Bladder Cancer

You have accessJournal of UrologyBladder Cancer: Invasive IV (PD38)1 May 2024PD38-09 PATHOLOGICAL COMPLETE RESPONSE TO NEOADJUVANT CHEMOTHERAPY IMPROVES ANTITUMOR IMMUNE RESPONSE THROUGH REDUCTION OF REGULATOTY T CELLS IN MUSCLE-INVASIVE BLADDER CANCER Daiki Ikarashi, Shigehisa Kitano, Tomohiko Matsuura, Shigekatsu Maekawa, Renpei Kato, Mitsugu Kanehira, and Wataru Obara Daiki IkarashiDaiki Ikarashi , Shigehisa KitanoShigehisa Kitano , Tomohiko MatsuuraTomohiko Matsuura , Shigekatsu MaekawaShigekatsu Maekawa , Renpei KatoRenpei Kato , Mitsugu KanehiraMitsugu Kanehira , and Wataru ObaraWataru Obara View All Author Informationhttps://doi.org/10.1097/01.JU.0001009424.64728.0c.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The prognosis for patients who achieve a pathologic complete response in bladder cancer is excellent, but the association between their prognosis and tumor microenvironment is still unknown. We focused the tumor immune microenvironment of pathological complete response after platinum-based neoadjuvant chemotherapy in patients with cT2-4aN0M0 bladder cancer using multiplex fluorescence immunohistochemistry. METHODS: We evaluated 12 pathological complete response patients who underwent radical cystectomy following neoadjuvant chemotherapy for cT2-4aN0M0 muscle-invasive bladder cancer, retrospectively. We assessed the density of several immune cell types in pretreatment and posttreatment tissues via multiplex fluorescence immunohistochemical analysis. RESULTS: The median age was 67 years; 10 patients were male. Nine (75%), and 3 (25%) patients were cT2, and cT3, respectively. 5-years PFS was 90%, and 5-years OS was 100%. The densities of regulatory T cell (Treg; CD3+CD4+FoxP3+ cell) were significantly decreased and almost disappeared in the tumor microenvironment of posttreatment tissue compared with pretreatment tissue. Other immune cells, such as effector T cells or M2 macrophages, were not significantly changed between posttreatment tissue and pretreatment tissue. CONCLUSIONS: In pathological complete response, Tregs in the tumor immune microenvironment were significantly decreased after platinum-based chemotherapy for muscle-invasive bladder cancer. The temporary arresting of immune response in the tumor microenvironment may reflect a favorable prognosis due to the decrease of Tregs with tumor shrinkage and improve the host tumor immune response. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e810 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Daiki Ikarashi More articles by this author Shigehisa Kitano More articles by this author Tomohiko Matsuura More articles by this author Shigekatsu Maekawa More articles by this author Renpei Kato More articles by this author Mitsugu Kanehira More articles by this author Wataru Obara More articles by this author Expand All Advertisement PDF downloadLoading ...