Mp45-07 Stone Formers With Higher Uric Acid Stone Composition and Elevated NLR Have an Increased Risk of CKD

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation II (MP45)1 May 2024MP45-07 STONE FORMERS WITH HIGHER URIC ACID STONE COMPOSITION AND ELEVATED NLR HAVE AN INCREASED RISK OF CKD Hsiu-Ting Tung, Chia-Min Liu, Ho-Shiang Huang, Ze‐Hong Lu, and Chan-Jung Liu Hsiu-Ting TungHsiu-Ting Tung , Chia-Min LiuChia-Min Liu , Ho-Shiang HuangHo-Shiang Huang , Ze‐Hong LuZe‐Hong Lu , and Chan-Jung LiuChan-Jung Liu View All Author Informationhttps://doi.org/10.1097/01.JU.0001008764.86460.8e.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urolithiasis is associated with an increased risk of chronic kidney disease (CKD), but limited research has specifically explored the risk of CKD associated with different stone types. Chronic inflammation plays a significant role in the progression of CKD, and neutrophil-to-lymphocyte ratio (NLR) has been proposed as a biomarker of inflammation, yet its use in predicting renal deterioration in patients with urolithiasis remains limited. We aimed to explore whether the combination of stone composition and NLR could be useful as a predictor for CKD risk. METHODS: A total of 336 stone formers who had received endoscopic treatment and had at least one stone submission for analysis were enrolled in this retrospective study. Stones were classified into uric acid, calcium oxalate, and calcium phosphate groups. Renal functions were assessed at least one month after stone treatment. Clinical characteristics including demographic information, comorbidities, stone compositions, and laboratory test results were analyzed to identify risk factors of CKD. RESULTS: Uric acid stone formers had significantly lower estimated glomerular filtration rate (eGFR) compared with calcium stone formers (p<0.001). NLR was significantly higher in uric acid stone formers (p=0.005), and a significantly negative correlation between NLR and eGFR had been observed only in uric acid stone group. Univariate and multivariate logistic regression analyses showed that higher proportion of uric acid stone composition and higher NLR were both significantly associated with CKD risks. A nomogram integrating the independent predictors was generated for CKD prediction, and an ROC analysis revealed an AUC of 0.811 (0.764-0.858, p<0.001). CONCLUSIONS: Our study demonstrated that stone formers with higher proportion of uric acid composition and higher NLR levels have increased risk of CKD, and the prediction of CKD risk in stone formers could be improved by incorporating both factors. Download PPTDownload PPT Source of Funding: This research was supported by the National Cheng Kung University Hospital of Taiwan NCKUH-11202005 and the Ministry of Science and Technology of Taiwan (MOST 112-2314-B-006-058) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e744 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hsiu-Ting Tung More articles by this author Chia-Min Liu More articles by this author Ho-Shiang Huang More articles by this author Ze‐Hong Lu More articles by this author Chan-Jung Liu More articles by this author Expand All Advertisement PDF downloadLoading ...