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You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) II (MP14)1 May 2024MP14-06 IMPACT OF ABIRATERONE ON SEXUAL FUNCTION IN MEN WITH ADVANCED PROSTATE CANCER: A META-ANALYSIS OF RCTS Alec Zhu, Aaron Brant, Xian Wu, Camilo A. Gallo, Manish Kuchakulla, Adithya Balasubramanian, Lina Posada, Leo Dreyfuss, Mary O. Strasser, Tenny R. Zhang, Robert Fisch, Brandon M. Wahba, Gal Wald, and Jonathan E. Shoag Alec ZhuAlec Zhu , Aaron BrantAaron Brant , Xian WuXian Wu , Camilo A. GalloCamilo A. Gallo , Manish KuchakullaManish Kuchakulla , Adithya BalasubramanianAdithya Balasubramanian , Lina PosadaLina Posada , Leo DreyfussLeo Dreyfuss , Mary O. StrasserMary O. Strasser , Tenny R. ZhangTenny R. Zhang , Robert FischRobert Fisch , Brandon M. WahbaBrandon M. Wahba , Gal WaldGal Wald , and Jonathan E. ShoagJonathan E. Shoag View All Author Informationhttps://doi.org/10.1097/01.JU.0001009428.69695.82.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: New anti-androgens demonstrate improved survival in men with advanced prostate cancer. However, the impact of these medications on sexual function is unclear. We used quality-of-life data from randomized clinical trials (RCTs) evaluating abiraterone acetate (AA) in men with metastatic prostate cancer to characterize the effect of anti-androgens on erectile and sexual function. METHODS: We identified seven clinical trials (COU301, COU302, PCR2023, PCR3011, PCR4011, PRO3001, PRO3002) within the Yale University Open Data Access (YODA) repository evaluating AA in patients with metastatic castration-sensitive or castration-resistant prostate cancer. Patients who completed the Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire before and after treatment were included. Responses to question 'BL5' corresponded to erectile function, and responses to question 'GS7' corresponded to sexual function satisfaction. The main outcomes were changes in erectile function and sexual satisfaction sub-scores from baseline to 3, 6, and 12 months. To compare the effect of AA between treatment and control groups, meta-analysis was performed in the five RCTs to estimate the standardized mean differences (SMD) in change of FACT-P sub-scores between the two treatment arms. RESULTS: A total of 7,353 patients were identified from the seven trials within YODA. The SMDs in erectile function (A) and sexual satisfaction (B) scores at 3, 6, and 12 months between the treatment and control groups were determined for each trial (Figure 1). Heterogeneity was assessed and meta-analysis of the RCTs demonstrated no statistically significant changes in erectile function or sexual satisfaction sub-scores at 3 and 6 months between the two treatment arms. At 12 months, overall SMDs were -0.02 (95% CI -0.12, 0.08) for erectile function and -0.05 (95% CI -0.21, 0.11) for sexual satisfaction with a fixed-effects model, and overall SMDs were -0.02 (95% CI -0.20, 0.16) for erectile function and -0.05 (95% CI -0.21, 0.11) for sexual satisfaction with a random-effects model. CONCLUSIONS: Meta-analysis of quality-of-life data from RCTs reveals AA does not significantly impact erectile function or sexual satisfaction relative to control treatments in men with metastatic prostate cancer. Download PPT Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e221 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Alec Zhu More articles by this author Aaron Brant More articles by this author Xian Wu More articles by this author Camilo A. Gallo More articles by this author Manish Kuchakulla More articles by this author Adithya Balasubramanian More articles by this author Lina Posada More articles by this author Leo Dreyfuss More articles by this author Mary O. Strasser More articles by this author Tenny R. Zhang More articles by this author Robert Fisch More articles by this author Brandon M. Wahba More articles by this author Gal Wald More articles by this author Jonathan E. Shoag More articles by this author Expand All Advertisement PDF downloadLoading ...
Zhu et al. (Mon,) studied this question.