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Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia which is considered to be a primary cause of treatment resistance observed in these tumors. Desmoplasia also plays a major role in mediating an immunosuppressive microenvironment and restricting immune cell infiltration in PDAC. In this study, using a syngeneic orthotopic immunocompetent KPC PDAC model, we demonstrate that PDT using Visudyne® can alter the tumor microenvironment, enhances immune cell infiltration, significantly reducing tumor growth and increasing survival in combination with anti-PD1.
Saad et al. (Tue,) studied this question.