Dexa Screening in CKD-Mbd: A Key to Preventing Osteoporosis

Introduction: Many individuals aficted with Chronic kidney disease (CKD), particularly those in stages 3 to 5, exhibit a substantial decline in bone mineral density, leading to an increased vulnerability to fractures and a notable surge in related morbidity and mortality. Moreover, Chronic kidney disease–mineral and bone disorder (CKD-MBD) remains inadequately investigated within this population. Thus, this study aimed to elucidate the metabolic bone prole of CKD patients utilizing DEXA (dual x-ray absorptiometry). In this cross-sectional study, patients diagnosed with stages 3, 4, and 5 CKD were Material and Methods: assessed. The serum concentrations of calcium, phosphorus, intact parathyroid hormone (iPTH), 25-hydroxy vitamin D, and total alkaline phosphatase were determined for all participants. Additionally, bone mineral density (BMD) was evaluated at the neck of the femur (NOF), lumbar spine (LS), and distal end of radius using dual-energy X-ray absorptiometry (DEXA) The prevalence rates of various b Results: iochemical abnormalities were as follows: hypocalcemia (85%), hyperphosphatemia (74%), elevated alkaline phosphatase (89%), secondary hyperparathyroidism (68%), vitamin D deciency (60%), and vitamin D insufciency (26%). Osteoporosis, as determined by the femoral neck T-Score, was identied in 35 patients (35%), while 47 patients (47%) displayed osteoporosis at the lumbar spine (LS). Additionally, osteoporosis was detected in 40 patients at the radius. This data indicates a trend wherein as CKD advances to later stages, there is a notable increase in the prevalence of osteoporosis and osteopenia, with a particular emphasis on the lumbar spine. Hence, CKD represents a substantial ris Conclusion: k factor for osteoporosis, independent of conventional risk factors. We emphasize the importance of early screening, identication, and management of osteoporosis to alleviate the related morbidity and mortality within this specic patient cohort.