(APACHE II score, Mortality and length of ICU stay in patients with systemic inflammatory response syndrome)

Background: sepsis is a life-threatening disorder involving disseminated organ injury due to systemic inflammatory response that mediate direct tissue injury. Aim and objectives: The major objective of this research is to identify factors that increase the risk of death for intensive care unit survivors. Finding out what factors influence these patients' length of time spent in the intensive care unit (LOS) is a secondary objective. Patients and methods: This observational study was conducted on 53 patients at Minia University Hospitals, intensive care unit. Results: The positive connection between APACHE II and duration of stay in the intensive care unit was statistically significant. Median of APACHE II was 6 with IQR (3-9). Median of ICU stays was 6.5 with IQR (5-8). Mortality rate was 13%. At cut off point >9.5, Sensitivity was 85.7% and specificity was 87% in APACHE II score for prediction of mortality with highly statistical significance. Conclusion: APACHE II score has a benefit predictive role in detection of mortality in systemic inflammatory response syndrome (SIRS) patients with 85.7 % sensitivity and 87 % specificity with highly statistical significance. Key words: APACHE II score, Mortality, systemic inflammatory response syndrome, ICU stay.