Abstract Hyperleukocytosis is defined as a white blood cell count exceeding 100,000/µL and is a critical manifestation of acute and chronic leukemia. It can lead to life‐threatening complications such as leukostasis, disseminated intravascular coagulation, and tumor lysis syndrome. Leukostasis results from microvascular obstruction by leukemic blasts, causing multisystemic manifestations. Leukostasis is primarily a clinical diagnosis requiring prompt recognition and intervention. Supportive care includes intravenous hydration, uric acid‐lowering agents, and cautious blood transfusions to prevent worsening hyperviscosity. Hydroxyurea and cytarabine are used as cytoreductive agents until a definitive diagnosis and management are started. The role of leukapheresis is controversial, and practice patterns differ between clinicians and institutions.
Baral et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: