October 13, 2025Open Access

Comparison of venous lactate values on blood gas analyser versus laboratory autoanalyser: A preliminary study

Key Points

Lactate levels measured by blood gas analyser and laboratory autoanalyser showed comparable results, but critical discrepancies occurred.
The mean difference in lactate values was 0.34 mmol/L, which was not statistically significant (P = 0.062).
Statistically significant correlation existed between the two methods with a Spearman coefficient of 0.816 (P < 0.001).
Higher variability in differences was noted when lactate exceeded 2 mmol/L, suggesting the need for consistent monitoring tools.

Abstract

Background both have their advantages. Studies have compared lactate and electrolyte values on arterial blood; none used venous samples which are preferred in children. We planned to compare venous lactate by BGA and AA in children admitted to Paediatric Intensive Care Unit (PICU). Methods Fifty children aged one month to 18 yr admitted in PICU were included in the study after parental consent. Paired venous samples were collected in heparinised syringes for BGA, in fluoride containing vacutainers for AA and were analysed immediately. Results Lactate levels were assessed in 29 male and 21 female children Median age: 4 yr interquartile range (IQR)=1-10). AA reported higher lactate levels but mean difference between two methods (0.34±1.56 mmol/L) was not statistically significant ( P = 0.062). The methods showed statistically significant correlation [95% confidence interval (CI), Spearman correlation coefficient (rs)=0.816, P =2 mmol/L) which represent critically ill children. Use of the same analyser, either BGA or AA, is therefore recommended for monitoring.

Comparison of venous lactate values on blood gas analyser versus laboratory autoanalyser: A preliminary study

Key Points

Abstract

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