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October 13, 2025

Efficacy of Dexmedetomidine Compared to Fentanylas Intrathecaladjuvant to Bupivacaine: A Double-Blind Randomized Study

Key Points

Dexmedetomidine improved sensory block onset and duration compared to fentanyl in spinal anaesthesia.
Patients receiving dexmedetomidine experienced a faster onset of motor block and prolonged analgesia.
Haemodynamic stability was comparable between both groups, indicating safety in using dexmedetomidine.
Overall block characteristics support dexmedetomidine as a superior option for intrathecal analgesia in lower limb surgery.

Abstract

Background p<0.001) and lasted longer (186.8 ± 21.1 vs. 173.6 ± 7.9 min; p=0.003). Motor block onset was quicker in Group D (10.0 ± 2.0 vs. 11.2 ± 2.4 min; p=0.034) and duration was prolonged (144.6 ± 14.9 vs. 130.7 ± 12.9 min; p<0.001). Haemodynamic stability and side effects were comparable. Conclusion: Dexmedetomidine as intrathecal adjuvant provided superior block characteristics and prolonged analgesia compared to fentanyl, with stable haemodynamics and minimal side effect

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Efficacy of Dexmedetomidine Compared to Fentanylas Intrathecaladjuvant to Bupivacaine: A Double-Blind Randomized Study

Key Points

Abstract

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