October 17, 2025

Supplementary Figure 6 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Key Points

Mutations were detected in both tumor tissue and plasma DNA of patients receiving trametinib.
Among patients with nf1 mutations, the presence of genomic alterations correlates with treatment response.
This analysis utilized stratification to differentiate patient responses based on overall outcomes.
Findings underline the potential for plasma dna genotyping to complement tumor tissue analysis in cancer treatment.

Abstract

Supplementary Figure 6. Genomic alterations detected in patients treated in subprotocol S1 enrolling patients with NF1 mutations who received treatment with trametinib. Patients are stratified according to the best overall response. Triangles are used to depict the presence of mutation in tissue (lower triangle) and/or plasma (upper triangle).

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Cite This Study

Gouda et al. (Wed,) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcab6 https://doi.org/https://doi.org/10.1158/1078-0432.30363471

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