Standardizing Somatic and Germline Molecular Testing in Prostate Cancer: Care Pathway and EHR Applications

Clinical guidelines recommend tumor testing for patients with metastatic prostate cancer (mPC), but testing rates remain inconsistent across patient populations. To address this, we developed a care pathway and investigated opportunities to leverage the electronic health record (EHR) to standardize testing workflows and support practices in the United States. Using a modified Delphi methodology approach with a hybrid offline and live format, we conducted an online survey and panel discussion with live polling to identify opportunities for improvement and real-world implementation considerations. Based on the identified barriers, clinical guidelines, and real-world practices, we developed a care pathway and three clinical resources covering EHR applications. These tools guide the use of EHR automation to improve patient identification, enhance clinical decision-making, and optimize the integration of tumor and germline testing into clinical workflows across care settings. The results of this study may support practices in standardizing molecular testing and may reduce care inequities for patients with mPC.