ABSTRACT Fascia has historically been viewed as passive connective tissue packaging, but emerging evidence suggests a more complex and integrated role. We propose a theoretical mechanometabolic framework that conceptualizes fascia as reticulated, sheet‐like structures investing micro‐ and macro‐environments with dynamic components including blood, lymph, cerebrospinal fluid, and adipose tissue. This framework synthesizes evidence from embryology, biomechanics, cellular biology, and systems physics to suggest fascia functions as an active mechanosensitive network. While certain aspects of this framework, including fasciacyte identification and viscoelastic properties, are experimentally validated, others, such as critical phenomena, phase transitions, and comprehensive mechanometabolic integration, remain theoretical and require direct experimental validation. Clinical applications, particularly hydrodissection techniques that exploit fascial plane architecture, provide indirect support for discrete mechanometabolic compartmentalization, though mechanistic understanding requires further investigation. This manuscript presents both established findings and testable hypotheses, proposing experimental pathways to validate this integrative framework. Understanding fascia as a mechanometabolic system may have implications for anatomy education, manual therapy, surgical technique, and our broader conceptualization of human physiology.
John C. Ferguson (Wed,) studied this question.