Design, synthesis, and multi-target anticancer evaluation of 1,3-thiazolodin-4-one analogues against breast cancer: mechanistic insights into estrogen metabolism, inflammation, angiogenesis, and oxidative stress
To design and evaluate the anticancer effects of 1,3-thiazolodin-4-one analogues against breast cancer.
Synthesis of 1,3-thiazolodin-4-one analogues
Multi-target evaluation against breast cancer
Assessment of estrogen metabolism, inflammation, angiogenesis, and oxidative stress mechanisms
1,3-thiazolodin-4-one analogues showed significant antitumor activity against breast cancer cells
Mechanistic insights included modulation of inflammation and oxidative stress
Potential pathways affected include estrogen metabolism and angiogenesis
Abstract
Breast cancer remains a leading cause of mortality in women, underscoring the need for multitarget therapeutic agents.
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Design, synthesis, and multi-target anticancer evaluation of 1,3-thiazolodin-4-one analogues against breast cancer: mechanistic insights into estrogen metabolism, inflammation, angiogenesis, and oxidative stress | Synapse