Chemical engineers have played a vital role in the pharmaceutical industry for more than a century, bridging the gap between scientific discovery and large-scale drug manufacturing. This review examines the evolution in the role of chemical engineers and their impact on the development of small molecules, biologics, and emerging modalities such as oligonucleotides and gene therapies. We provide historical context, from early breakthroughs in insulin and penicillin production to the integration of continuous processing and advanced modeling. Key areas of focus include reaction engineering, separations, crystallization, fluid dynamics, process control, and continuous manufacturing. Looking ahead, chemical engineers will be central to addressing challenges in sustainability, advanced delivery systems, and the application of artificial intelligence and data-driven technologies. As therapeutic complexity grows, the application of engineering fundamentals, integrated with life and natural sciences, remains essential for ensuring safe, efficient, and scalable manufacturing of medicines that advance global health.
Collins et al. (Wed,) studied this question.