Antiplatelet activity and cytotoxicity assessment of Morita-Baylis-Hillman-based alcohol, acetate, and phosphonate derivatives

Key Points

• To evaluate the antiplatelet activity and cytotoxicity of Morita-Baylis-Hillman derivatives.
• Synthesize alcohol, acetate, and phosphonate derivatives from Morita-Baylis-Hillman adducts.
• Assess antiplatelet activity using in vitro assays.
• Evaluate cytotoxicity of the derivatives.
• Identified several derivatives with significant antiplatelet activity.
• Demonstrated selectivity of MBH adducts as antiplatelet agents.
• Noted a favorable cytotoxicity profile for select derivatives.