Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy

Key Points

• This research aims to identify early changes in gene expression and pathology linked to Fuchs endothelial corneal dystrophy in mutant mice.
• Used Col8a2Q455K/Q455K mutant mouse model to analyze corneal endothelium.
• Assessed changes in transcriptomic profiles and pathologic alterations.
• Evaluated the activation of ECM remodeling, ER stress, and immune responses.
• Detected early activation of ECM remodeling and ER stress in corneal endothelium.
• Observed immune responses preceding noticeable pathology in mutants.
• Identified potential early biomarkers for therapeutic intervention.