What question did this study set out to answer?

To develop efficient and biosafe sonosensitizers for enhanced sonodynamic antibacterial therapy targeting biofilms.

January 26, 2026Journal of Materials Chemistry B0 citations

AIE-active anthraquinone-derived sonosensitizers with enhanced reactive oxygen species generation for ultrasonic biofilm eradication

DDDongmei DengGuangdong University of Technology JCJunjie ChenGuangdong University of Technology HMHaijian MengGuangdong University of Technology

Key Points

To develop efficient and biosafe sonosensitizers for enhanced sonodynamic antibacterial therapy targeting biofilms.
Synthesis of AIE-active anthraquinone-derived sonosensitizers
Evaluation of sonosensitizer efficacy using ultrasonic treatment
Measurement of reactive oxygen species generation
Assessment of biofilm eradication efficiency
Significant enhancement in reactive oxygen species generation compared to previous sonosensitizers
Effective eradication of biofilms in various conditions
Demonstrated biosafety in initial assessments

Abstract

The development of highly efficient and biosafe sonosensitizers remains a significant challenge for sonodynamic antibacterial therapy. Herein, we report a novel class of aggregation-induced emission (AIE)-active anthraquinone-derived sonosensitizers (AQ and...

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