Renal denervation increased basal renal blood flow by 35% in congestive heart failure and 21% in spontaneously hypertensive rats, improving autoregulation.
Does acute renal denervation improve dynamic autoregulation of renal blood flow in rats with normal and increased renal sympathetic nerve activity?
Acute renal denervation increases basal renal blood flow and alters dynamic autoregulation in rat models of heart failure and hypertension, highlighting the role of sympathetic nerve activity in stabilizing glomerular filtration rate.
Absolute Event Rate: 0% vs 0%
Vasoconstrictor intensities of renal sympathetic nerve stimulation elevate the renal arterial pressure threshold for steady-state stepwise autoregulation of renal blood flow. This study examined the tonic effect of basal renal sympathetic nerve activity on dynamic autoregulation of renal blood flow in rats with normal (Sprague-Dawley and Wistar-Kyoto) and increased levels of renal sympathetic nerve activity (congestive heart failure and spontaneously hypertensive rats). Steady-state values of arterial pressure and renal blood flow before and after acute renal denervation were subjected to transfer function analysis. Renal denervation increased basal renal blood flow in congestive heart failure (+35 ± 3%) and spontaneously hypertensive rats (+21 ± 3%) but not in Sprague-Dawley and Wistar-Kyoto rats. Renal denervation significantly decreased transfer function gain (i.e., improved autoregulation of renal blood flow) and increased coherence only in spontaneously hypertensive rats. Thus vasoconstrictor intensities of renal sympathetic nerve activity impaired the dynamic autoregulatory adjustments of the renal vasculature to oscillations in arterial pressure. Renal denervation increased renal blood flow variability in spontaneously hypertensive rats and congestive heart failure rats. The contribution of vasoconstrictor intensities of basal renal sympathetic nerve activity to limiting renal blood flow variability may be important in the stabilization of glomerular filtration rate.
DiBona et al. (Tue,) reported a other. Renal denervation increased basal renal blood flow by 35% in congestive heart failure and 21% in spontaneously hypertensive rats, improving autoregulation.