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February 2, 2026Open Access

MicroRNAs as potential prognostic biomarkers in acute lymphoblastic leukemia: a systematic review, meta-analysis, and bioinformatics study

STSamaneh ToutounchianTehran University of Medical Sciences KBKiyarash BehboodiTehran University of Medical Sciences MAMona AlinejadfardUniversity of Tehran

Key Points

To evaluate the role of microRNAs as prognostic biomarkers in acute lymphoblastic leukemia and explore their therapeutic potential.
Conducted a systematic review and meta-analysis of existing studies on microRNAs in acute lymphoblastic leukemia.
Constructed a competing endogenous RNA (ceRNA) network to understand the regulatory mechanisms of these miRNAs.
Identified the significance of context-dependent roles of miRNAs in the prognosis of acute lymphoblastic leukemia.
Supported the value of microRNAs as prognostic biomarkers in acute lymphoblastic leukemia.
Highlighted the need for large, multicenter trials to confirm the findings.
Provided insights into the regulatory mechanisms of microRNAs, opening new directions for therapy.

Abstract

These findings support miRNAs as valuable prognostic biomarkers for ALL with potential for personalized therapy. The context-dependent role of these miRNAs highlights the need for confirmation through large, multicenter trials. The constructed ceRNA network provides useful insights into their regulatory mechanisms, opening new directions for therapeutic strategies.

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Cite This Study

Toutounchian et al. (Thu,) studied this question.

synapsesocial.com/papers/6980fb97c1c9540dea80d727 https://doi.org/https://doi.org/10.1186/s13643-026-03083-3

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