Exogenous testosterone use in young men was associated with significantly reduced stroke odds (OR 0.47, 95% CI: 0.25–0.91; p < 0.02) compared to non-exposed controls.
Does exogenous testosterone prescription reduce the odds of stroke in young men aged 18-55?
Exogenous testosterone prescription in young men is associated with significantly lower odds of stroke, though limited by small exposure numbers and lack of dosing details.
Absolute Event Rate: 0% vs 0%
Introduction: Low testosterone levels are associated with increased risk for cardiovascular disease, including ischemic stroke. The relationship between supratherapeutic testosterone use and stroke risk in young men remains unexplored. We present an exploratory analysis evaluating the stroke risk with exogenous testosterone use in men using Colorado claims data Hypothesis: Stroke risk is increased at low and supratherapeutic testosterone levels but reduced at optimal levels Methodology: We conducted a secondary analysis of retrospective case–control data from Colorado’s All Payer Claims Database (2012–2019). Exogenous testosterone exposure was defined as a prescription within 1 year before index stroke in male sex aged 18–55. Stroke cases were matched to controls (without stroke) by age, sex, prestroke period, and insurance. Conditional logistic regression assessed stroke odds by testosterone exposure compard to no exposure, controlling for socioeconomic status, language, and sum of cardiovascular p 3 risk factors. However, among men with hypogonadism, only a small fraction received testosterone in both groups, suggesting careful selection of patients for exogenous testosterone. The model captured only prescription testosterone, without distinguishing therapeutic versus supratherapeutic. The model did not account for off-label use. Baseline levels, dose, route, preparation, and indication were not available. Small number of testosterone-exposed individuals limits the strength and generalizability of this finding. Prospective studies are needed to clarify the relationship between testosterone exposure and stroke risk
Dengri et al. (Thu,) reported a other. Exogenous testosterone use in young men was associated with significantly reduced stroke odds (OR 0.47, 95% CI: 0.25–0.91; p < 0.02) compared to non-exposed controls.