What question did this study set out to answer?

The aim is to determine the role of elevated FSTL1 levels in DLBCL and their clinical implications.

February 2, 2026Biomedicine & Pharmacotherapy0 citationsOpen Access

FSTL1 contribute to aggressive clinical behavior in DLBCL may by activating the DIP2A/ICAM-1-mediated adhesion mechanism

XLXiping Xiping Liang XZX. ZhangChongqing Cancer Hospital CWChaoyu WangChongqing University

Key Points

The aim is to determine the role of elevated FSTL1 levels in DLBCL and their clinical implications.
Measured FSTL1 levels in DLBCL samples
Analyzed clinical characteristics and outcomes
Investigated the DIP2A/ICAM-1 adhesion mechanism
High FSTL1 levels correlate with advanced DLBCL features
FSTL1 is linked to increased drug resistance
DIP2A/ICAM-1 pathway plays a key role in this mechanism

Abstract

Our findings indicate that elevated FSTL1 levels may contribute to advanced clinical characteristics and worse outcomes in DLBCL. FSTL1 contributes to drug resistance likely through DIP2a/ICAM-1-mediated adhesion mechanism.

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