α-tocopherol alleviates ketamine toxicity in rat brain neurons

Key Points

• This research aims to investigate the protective effects of α-tocopherol on ketamine-induced toxicity in rat brain neurons.
• Assessed oxidative stress levels in neurons exposed to ketamine
• Evaluated membrane integrity through biochemical assays
• Measured apoptosis signaling pathways in neuronal cells
• α-tocopherol significantly reduced oxidative stress in neurons
• It preserved membrane integrity when neurons were treated with ketamine
• There was a decrease in apoptosis signaling markers in the presence of α-tocopherol