With the acceleration of the global aging process, healthy aging is a topic of substantial current interest. Sarcopenia is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function, which is associated with the gut microbiome. To investigate the intervention between aging-related gut microbiome and sarcopenia, we conducted fecal microbiota transplantation (FMT) experiments on male germ-free (GF) mice, dividing them into three groups: those receiving transplants from healthy elderly individuals (HM group), those receiving from sarcopenia patients (SM group), and a subgroup of the SM group supplemented with probiotic BFS1243 (SML group). And then, those gut microbiomes and their metabolites, inflammatory factors, muscle mass, muscle functions, etc. were be detected.
曾琦(Qi Zeng) (Thu,) studied this question.