The T peak to T end (TpTe) interval was positively correlated with E/e' (r=0.324, p=0.001) and global longitudinal strain (r=0.689, p<0.001) in newly diagnosed hypertensive patients.
Observational (n=100)
The ECG parameter TpTe correlates with echocardiographic markers of diastolic dysfunction and global longitudinal strain, suggesting it could serve as an early, non-invasive marker of diastolic electromechanical coupling in newly diagnosed hypertension.
Effect estimate: r = 0.324
p-value: p=0.001
Abstract Background Asymptomatic diastolic dysfunction may be present for a significant time before developing into symptomatic heart failure. While two-dimensional echocardiography conventionally detects changes in LV diastolic and systolic function. ECG variables such as the interval from T peak to T end (TpTe) and QT interval in the ECG have been suggested to be an index of transmural dispersion of repolarization and a marker of left ventricular relaxation. Combining the two modalities, obtained in routine clinical practice, allows non-invasive evaluation of diastolic electromechanical coupling. Purpose The aim is to study the association between ventricular repolarization variables and cardiac diastolic function in newly diagnosed hypertensive patients. Methods The study population included 100 patients with newly diagnosed hypertension. ECG was analysed by Philips Intelli Space ECG machine, which included the measurement of T peak to T end interval, QRS duration, and QTc interval. Phillips- EPIC 7C Echocardiography machine was used to assess diastolic function and speckle tracking was used for assessment of global longitudinal strain. Results The e′ inversely correlated with TpTe (r = − 0.365, p 0.001), whereas E/e′ was positively correlated with TpTe (r = 0.324, p = 0.001) and TR peak velocity was positively correlated with TpTe (r = 0.661, p 0.001. The correlation between ventricular repolarization variables and GLS was also seen with GLS positively correlated with TpTe (r = 0.689, p 0.001). There was no statistically significant correlation between QTc and echocardiographic parameters(Table 1 and Figure 1). Conclusion Early non-invasive evaluation of diastolic electromechanical coupling in newly diagnosed hypertension patients is clinically useful for predicting the outcome and early intervention can improve prognosis. The correlation of TpTe with e′ and E/e′ in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. TpTe can predict an elevated E/e′, which has been established as a prognostic marker in many cardiac disorders. An elevated E/e′ should be suspected when TpTe is prolonged (95 ms).Table 1 Figure 1
Kaushik et al. (Sat,) conducted a observational in newly diagnosed hypertension (n=100). Ventricular repolarization variables (TpTe, QTc) vs. Echocardiographic parameters (diastolic function, GLS) was evaluated on Correlation between TpTe and E/e' (r = 0.324, p=0.001). The T peak to T end (TpTe) interval was positively correlated with E/e' (r=0.324, p=0.001) and global longitudinal strain (r=0.689, p<0.001) in newly diagnosed hypertensive patients.