What question did this study set out to answer?

To compare the effects of clomipramine administered via different routes on its antidepressant activity.

February 8, 2026

Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study.

ASA.E. SalamaNational Research Centre RKRabab KamelNational Research Centre NGNourina GhoneimEgyptian Government

Key Points

To compare the effects of clomipramine administered via different routes on its antidepressant activity.
Compared intranasal and oral clomipramine administration.
Assessed antidepressant activity and neurological toxicity.
Utilized clomipramine-loaded nanocomplexes in trials.
Intranasal route showed enhanced antidepressant activity compared to oral administration.
Clomipramine nanocomplexes alleviated neurological toxicity effectively.

Abstract

Clomipramine-loaded NC administered via intranasal route showed an enhanced effect and a higher antidepressant activity than the traditional oral route through alleviating CPX neurological toxicity.

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